On the contrary to setting up web graphics, when you set up graphics for print, you can allow your file size to be large. Since you only have to get the file to the printer once there is no need to worry about its size, once its printed its there for good. When something is printed it does not have the help of pixels to illuminate the graphic therefore a much higher resolution is needed. 300 dpi(dots per inch) is the standard for print graphics. Use CMYK for your color settings and it is better to scale your graphics by inches and centimeters rather than by pixels. Have you ever seen a graphic or a picture in a magazine or catalog that looks pixelated? That is because the designer probably had the resolution set to web(72 dpi) instead of print(300dpi). Here is a print catalog that I designed for Wave Rave Snowboard Shop that was distributed nationwide in 2008.
Here are a few more examples of print ads I did while working for Wave Rave.